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Publications

2025

Cold and hot fibrosis define clinically distinct cardiac pathologies

Shoval Miyara*, Miri Adler*, Kfir Baruch Umansky,  Daniel Häußler, Elad Bassat, Yalin Divinsky, Jacob Elkahal, David Kain, Daria Lendengolts, Ricardo O. Ramirez Flores, Hanna Bueno Levy, Ofra Golani, Tali ShalitMichael GershovitsEviatar WeizmanAlexander GenzelinakhDanielle M. KimchiAvraham ShakkedLingling ZhangJingkui WangAndrea BaehrZachary PetroverRachel SarigTatjana Dorn, Alessandra MorettiJulio Saez-RodriguezChristian KupattElly M. TanakaRuslan MedzhitovAchim KrügerAvi MayoUri Alon, Eldad Tzahor, Cell Systems (2025)​​

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Tissue-level division of labor is coordinated across organs through universal programs and context-specific adaptations

Shira Yonassi, Noa Goldenberg, Avia Walfisch, Eitan Cohen, Einat Shaer Tamar, and Miri Adler, bioRxiv (2025)

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ParTIpy: A Scalable Framework for Archetypal Analysis and Pareto Task Inference

Philipp SL Schäfer, Leoni Zimmermann, Paul L Burmedi, Avia Walfisch, Noa Goldenberg, Shira Yonassi, Einat Shaer Tamar, Miri Adler, Jovan Tanevski, Ricardo O Ramirez Flores, Julio Saez-Rodriguez, bioRxiv (2025)

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A fibroblast-centric network drives cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma

Shoval Miyara, Shachaf Frenkel, Avi Mayo, Philippe Gascard, Michael Strasser, David Gibbs, Eviatar Weizman, Itay Ben Shalom, Yaniv Stein, Deng Pan, Joseph A Caruso, Veena Sangwan, Nicholas Bertos, Julie Berube, Sophie Camilleri-Broet, Spyridon Oikonomopoulos, Haig Djambazian, Kfir Baruch Umansky, Jacob Elkahal, Shimrit Mayer, Pierre-Olivier Fiset, Jiannis Ragoussis, Miri Adler, Eldad Tzahor, Sui Huang, Lorenzo Ferri, Thea D Tlsty, Ruth Scherz-Shouval, Uri Alon, bioRxiv (2025)

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Temporal control of axonal floor plate crossing through a combination of incoherent feedforward and feedback loops of gene regulatory network regulating Robo3 expression

Reut Sudakevitz-Merzbach, Madhuri Majumder, Gerard Elberg, Marah Bakhtan, Dina Rekler, Sophie Khazanov, Benjamin J Wheaton, Nissim Ben-Arie, Gilgi Friedlander, Chaya Kalchiem, Sara Ivy Wilson, Alexander Jaworski, Miri Adler, and Avihu Klar, bioRxiv (2025)

2024

Recurrent hyper-motif circuits in developmental programs

Miri Adler and Ruslan Medzhitov, bioRxiv (2024)​​

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2023

Tissue Biology: In Search of a New Paradigm

Miri Adler*, Arun R. Chavan*, and Ruslan Medzhitov, Annual Review of Cell and Developmental Biology (2023)

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Emergence of division of labor in tissues through cell interactions and spatial cues

Miri Adler*, Noa Moriel*, Aleksandrina Goeva*, Inbal Avraham-Davidi, Simon Mages, Taylor S. Adams, Naftali Kaminski, Evan Z. Macosko, Aviv Regev, Ruslan Medzhitov and Mor Nitzan, Cell Reports (2023)

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Circuit to target approach defines an autocrine myofibroblast loop that drives cardiac fibrosis

Shoval Miyara*, Miri Adler*, Elad Bassat, Yalin Divinsky, Kfir Baruch Umansky, Jacob Elkahal, Alexander Genzelinakh, David Kain, Daria Lendengolts, Tali Shalit, Michael Gershovits, Avraham Shakked, Lingling Zhang, Jingkui Wang, Danielle Miriam Kimchi, Andrea Baehr, Rachel Sarig, Christian Kupatt, Elly Margaret Tanaka, Ruslan Medzhitov, Avi Mayo, Uri Alon, Eldad Tzahor, bioRxiv (2023)

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An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis

Shuang Wang, Kenneth Li, Eliana Pickholz, Ross Dobie, Kylie P Matchett, Neil C Henderson, Chris Carrico, Ian Driver, Martin Borch Jensen, Li Chen, Mathieu Petitjean, Dipankar Bhattacharya, Maria I Fiel, Xiao Liu, Tatiana Kisseleva, Uri Alon, Miri Adler, Ruslan Medzhitov, Scott L Friedman, Science Translational Medicine (2023)

2022

2021

2020

2019

Continuum of Gene-Expression Profiles Provides Spatial Division of Labor within a Differentiated Cell Type

Miri Adler, Yael Korem Kohanim, Avichai Tendler, Avi Mayo, and Uri Alon, Cell Systems (2019)

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2018

Fold-change detection in biological systems

Miri Adler and Uri AlonCurrent Opinion in Systems Biology (2018)

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Circuit Design Features of a Stable Two-Cell System

Xu Zhou*, Ruth A. Franklin*, Miri Adler*, Jeremy B. Jacox, Will Bailis, Justin A. Shyer, Richard A. Flavell, Avi Mayo, Uri Alon, and Ruslan Medzhitov, Cell (2018)

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Endocytosis as a stabilizing mechanism for tissue homeostasis

Miri Adler, Avi Mayo, Xu Zhou, Ruth A. Franklin, Jeremy B. Jacox, Ruslan Medzhitov, and Uri Alon, PNAS (2018)

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2017

Optimal Regulatory Circuit Topologies for Fold-Change Detection

Miri Adler*, Pablo Szekely, Avi Mayo, and Uri AlonCell Systems (2017)

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2014

Logarithmic and Power Law Input-Output Relations in Sensory Systems with Fold-Change Detection

Miri Adler, Avi Mayo, and Uri AlonPLOS Computational Biology (2014)

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See full publication list on my google scholar profile
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